Correlation of Disorders of the Spatial Vision System (Strabismus) and Amblyopia by Changes in Neural-Reflex Excitability and Metabolic Disorders at the Stages of Restoration of Pre-, Perinatal Encephalopathy
Sevinj Salmanova; Elmar Kasimov; Nigar Aliyeva
National Ophthalmology Center after acad.Z.Aliyeva and Children’s Neurological Hospital
Introduction: From 2000 to 2010 in more than 2000 children studied the development mechanism,the dynamics of transformation,variants of the restoration of two major ophthalmic syndromes:delayed visual maturation syndrome (DVM) and syndrome of optokinetic desadaptation(SOKD).
Methods: The clinical-physiological and clinical-biochemical spectrum of the executed studies, the correct organization of planned recovery courses of treatment of these children has significantly expanded.It was found that at the stages of development (from the neonatal to the pubertal) children suffering from pre-perinatal encephalopathy (PPE) encounter different variants of neurohumoral regulation,which to some extent contribute to determining the direction of neuroplasticity.
Results: Recently we have been able to demonstrate the essential role of certain features of metabolically deterministic mechanisms on the formation and dynamics of strabismus, amblyopia, and the consequences of PPE as a whole.Subjecting general material to the statistical variation processing by drawing up histograms we found that:
Discussion: 1.DVM is in a direct causal dependence on the clinical characteristics of catecholamine excite-dumping syndrome;with the long-term stabilization of DVM can serve as a basis for the appearance and progression of unilateral or bilateral esotropia.2.There is a high degree of positive correlation between SOKD, esotropia and cholinergic irritation.3.Prolonged sympathetic activation of blood promotes consistent inhibition of insulin sensitivity and, thereby, leads to the stabilization of the ‘torpid’ type of glycemic curve under sugar loading in children with PPE.4.Prolonged intracranial distension and multistage interdependent metabolic dysfunctions lie in the basis of asthenopia, SOKD and cerebrosthenic manifestations.
Conclusion: Even simultaneous therapy, correction of each of the mutually correlating mechanisms, improves the quality of life of these children.
References: 1. Angcang Tang, MD, MS; Taolin Chen, PhD; Junran Zhang, PhD; Qiyong Gong, PhD; Longqian Liu, PhD. Abnormal Spontaneous Brain Activity in Patients With Anisometropic Amblyopia Using Resting-State Functional Magnetic Resonance Imaging. J AAPOS
September/October 2017 – Volume 54 · Issue 5: 303-310
2. Dima Andalib, MD; Alireza Javadzadeh, MD; Reza Nabai, MD; Yashar Amizadeh, MD Macular and Retinal Nerve Fiber Layer Thickness in Unilateral Anisometropic or Strabismic Amblyopia. J AAPOS July/August 2013 – Volume 50 · Issue 4: 218-221
3. Sandra Chandramouli. Cortical visual impairment (CVI) in children—an analysis of risk factors, clinical presentation and treatment outcome. J AAPOS. August 2016Volume 20, Issue 4, Page e12