Influences of Unilateral Posterior Lens Opacity on Visual Function and Ocular Structure
Duoru Lin, PhD; Jingjing Chen; Zhenzhen Liu, PhD; Fengqi Zhou, MD;Haotian Lin, MD, PhD; Weirong Chen, MD; Yizhi Liu, MD, PhD
State Key Laboratory of Ophthalmology, Zhongshan Ophthalmic Center, Sun Yat-sen University
Zhongshan Ophthalmic Center, Xian Lie South Road #54, Guangzhou, China
Introduction: To investigate the impairment of visual function and ocular structure in patients with unilateral posterior lens opacity, one type of congenital cataract (CC) in our novel CC category system, and to provide clinical treatment guidance for the current controversial options.
Methods: This study included 25 patients (aged 3-15 years) who were diagnosed with unilateral posterior CC at the Zhongshan Ophthalmic Center from 2015 to 2016. Ocular structures and visual evoked potential (VEP) were compared between two eyes by paired t-test.
Results: Compared with contralateral healthy eyes, larger corneal astigmatism and deeper anterior chamber depth were found in cataractous eyes. The P100 peak time of pattern VEP-60’in cataractous eyes were longer than those in contralateral healthy eyes. The amplitudes of both pattern VEP-60’and -15’in cataractous eyes were smaller than those in the contralateral healthy eyes. No obvious positive or negative linear relationship was found between best corrected visual acuity and parameters of VEP.
Discussion: Posterior CC has the most controversial treatment option among all our novel categories due to the seemingly mild lens opacity and small affected area. Results of this study showed that the ocular structures, subjective and objective visual function of patients with posterior cataracts were significantly impacted by lens opacity. Furthermore, visual electrophysiology examinations are necessary independent of the visual acuity.
Conclusion: For patients diagnosed with posterior cataracts based on our novel CC system, timely surgical intervention is considerable.
References: 1. Lin H, Lin D, Liu Z, et al. A Novel Congenital Cataract Category System Based on Lens Opacity Locations and Relevant Anterior Segment Characteristics. Invest Ophthalmol Vis Sci. 2016;57(14):6389-95.||2. McCulloch DL, Skarf B. Pattern reversal visual evoked potentials following early treatment of unilateral, congenital cataract. Arch Ophthalmol. 1994;112(4):510-8.