Delayed Resolution of Retinopathy of Prematurity
Mariam S. Ahmad, MD; Jennifer L. Patnaik, PhD; Tamara Thevarajah, MS; Anne M. Lynch, MD, MSPH; Emily A. McCourt, MD
University of Colorado School of Medicine
Introduction: We investigated the clinical course of infants with unresolved retinopathy of prematurity (ROP) at 50 weeks corrected gestational age (CGA). We compared clinical characteristics between infants whose ROP resolved before 50 weeks CGA and those with a delayed resolution of ROP.
Methods: A retrospective chart review was performed on the medical records of infants screened for ROP at our institutions between January 2008 and December 2016. Delayed resolution was defined as the presence of persistent ROP or immature retinal vasculature at >/=50 weeks CGA. Chi-square was used to compare infants with delayed resolution to infants without delayed resolution. Variables with a p-value </=0.05 were considered statistically significant.
Results: 990 infants were included in the analysis. 131 (13.2%) showed delayed resolution. Infants with more severe ROP (higher stage, lower zone, plus/pre-plus disease) and type II ROP were significantly more likely to have delayed resolution. Variables associated with delayed resolution (p</=0.05) included <28 weeks CGA at birth, =3rd percentile birth-weight, positive blood culture sepsis, necrotizing enterocolitis, and intraventricular hemorrhage. No infants required treatment for ROP after 50 weeks CGA.
Discussion: In our cohort, infants with more severe ROP, <28 weeks CGA at birth, low birth-weight, and neonatal complications were more likely to have delayed resolution of ROP. Infants with delayed resolution did not require treatment for ROP after 50 weeks CGA.
Conclusion: Clinicians may expect infants with more severe ROP or a more complex clinical course to have delayed resolution. Further studies are needed to determine if ROP exams after 50 weeks CGA are necessary.|
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