The Relationship between Severe Bronchopulmonary Dysplasia and Severe Retinopathy of Prematurity in a Colorado Cohort
Jasleen K. Singh, MD; Erica M. Wymore, MD, MPH; Brandie D. Wagner, PhD; Tamara S. Thevarajan, MS; John P. Kinsella, MD; Alan G. Palestine, MD; Anne M. Lynch, MD, MSPH; Emily A. McCourt, MD
University of Colorado-Denver
Introduction: Bronchopulmonary dysplasia (BPD) and Retinopathy of Prematurity (ROP) are two adverse sequelae of preterm birth associated with abnormal vascular development. Our purpose was to characterize the interrelationship between these two outcomes in a Colorado cohort.
Methods: We performed a retrospective review of infants screened for ROP at the University of Colorado Hospital and Children’s Hospital Colorado between January 2012 and July 2015. We classified ROP using the using the ET-ROP criteria and BPD by the 2010 Criteria from the National Institute for Child Health and Development. We examined the relationship between moderate-severe BPD and the development of severe ROP (Type 1 or 2) using univariate analysis and multivariable logistic regression with the odds ratio (OR) as a measure of association. Co-variates included gestational age (GA) and birth weight at delivery (BW).
Results: In the cohort (n = 660), 77 (12%) infants developed severe ROP and 220 (33%) infants developed moderate-severe BPD. We found a significant relationship between these two outcomes following adjustments for GA and BW (OR = 3.8, 95% CI = 2.0-7.1, P <0.01).
Discussion: We found a significant relationship between moderate-severe BPD with severe ROP.
Conclusion: We suggest that these two neonatal outcomes have links with a common pathogenesis.
References: Early Treatment For Retinopathy Of Prematurity Cooperative Group null. Revised indications for the treatment of retinopathy of prematurity: results of the early treatment for retinopathy of prematurity randomized trial. Arch Ophthalmol. 2003 Dec;121(12):1684-94.
Ehrenkranz RA, Walsh MC, Vohr BR, Jobe AH, Wright LL, Fanaroff AA, Wrage LA, Poole K. Validation of the National Institutes of Health Consensus Definition of Bronchopulmonary Dysplasia. Pediatrics. 2005;116;1353